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  • Chemical Biology

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    Shimano Bicycle Clipless Mountainbike Pedals and Specialized Size 42 shoes. USED

    Here’s some medicinal chemistry combined with synthetic biology for you. Many people are used to thinking in terms of finding small-molecule probes for various cell targets, and those are valuable things. But what if you want to control a certain population of (for example) ion channels, but there aren’t any compounds that will do the… Shimano Biopace 48 MTB Kettenblatt silver BCD 110mm 48 Zähne KULT 76g 1988
  • Chemical News

    Shimano BL-C600 Nexave V-Brake-Griffe avec Power Modulateur 1 Paire silver

    Shimano Deore XT M770 9-Speed FC-M770 Left Hand Crank Arm 175MM - Y1J198050 I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… Shimano BL-M785 lever unit right
  • Analytical Chemistry

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    I suppose I deserve this one. Some years ago on the blog, I wrote about my days in grad school having to learn about symmetries and vibrational spectroscopy. Sparingly has that knowledge come in handy since then, but the course is still a vivid memory for me, since that’s the clearest example I had yet… Read More
  • Cancer

    Making and Measuring Multivalency

    Here’s an unusual paper that’s studying receptor behavior on cell surfaces by use of atomic force microscopy. (Here’s the SI file, which is free to access). The authors took the marketed VEGF inhibitor vandetanib (VD6474) and attached it through linkers to the AFM tip, and then scanned around the surface of live human umbilical v… SHIMANO BM-E8010 Upper Case Assembly 200 - Y72U00018
  • Drug Assays

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    Shimano Deore XT M8000 Rear Brake A common question – well, it should be a common question, anyway – is “How do I make sure that this compound collection is a useful one to screen?” There are alternative forms that come down to the same issues – if you’re putting together a new focused screening set, what should be in it?… Read More
  • Biological News

  • Business and Markets

  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Analytical Chemistry

    A Look at Proteins in Living Cells

    We spend a lot of time in this sort of work thinking about protein structures. Traditionally that’s been the province of X-ray crystallography, later joined by solution NMR, and more latterly by cryo-electron microscopy. Each of these has its own set of advantages and disadvantages, but one big split is between the solid phase (X-ray… Shimano BR-M585 LX 160 FT
  • Academia (vs. Industry)

    Startup Culture, Starting

    Shimano Deore XT PD-M8040 Trail Pedals Set MTB Bike Small Medium New Retail Box Many readers of this blog work in the biopharma industry, naturally, and of those, many are in and around the (few) locations where a great many of the companies in the industry are born. I myself am in the Boston/Cambridge area, famously thick with companies large and small, and then you have the Bay area… Shimano BR-MT520 4-Piston Disc Brake Caliper with Metal Pads, Front or Rear
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